May 22, 2012

Merial rep points out my mistake!

Well look at that I have made a mistake. Merial the drug company that I have been waiting to release the recombinant DNA vaccine for the Influenza virus has already done so. In fact they released the vaccine last year!!! December 4th 2006 they announced that they added it to their line and submitted a press release about the Recombitek Influenza Vaccine. The Horse magazine picked it up as well as several other magazines, but why have I not heard about it? Why no major promotion? I feel this is a huge advancement in the fight against improper vaccines, vaccines that will possibly have less reactions and much better protection!

So thanks to Mary Jane, a Merial Sales rep, for pointing out my mistake in this post here -

http://www.horsekinetics.com/australia-to-test-out-proteqflu

The Flu vaccine is available, however I will want to find out if there are any differences between the Recombitek Influenza Vaccine and the Proteq Flu found in Europe. I will let you all know what I find out.

Equine Rhino Vaccination – is it worth it?

It is the fall season and many people are inquiring about what vaccinations they should give their horse. Equine Rhino, Equine Influenza, Potomac Horse Fever, and Rabies are the common ones asked for in this area of the US. However are they worth it? Do you actually know what they do and how they protect? Did you know that many times they do not protect at all like you think they should?

Equine Rhinopneumonitis, one of my favorite diseases to bash the vaccine. Why bash the vaccine? Well to put it bluntly and simply, because it doesn’t work in protecting your horse. This is a herpes virus and like the herpes viruses in humans it can infect the animal for life. The virus remains dormant and the horse will not show signs of infection, this is called latency. However during periods of stress, such as show season, out breaks can occur. The vaccine for rhino does not appear to be able to prevent these outbreaks and is questionable as to whether it even helps stem the signs and symptoms. The disease causes respiratory signs, abortions and infrequently a paralyzing neurologic disease with similar signs as the infamous Equine Protozoal Myelitis (EPM). The neurologic form has been in the news for the past couple of years because there appears to be a very virulent strain causing the neuroplogic form that has closed racetracks in Maryland and has had a very large impact on the horse industry where ever it has been found. The vaccines for rhino do not produce antibodies in all horses, in fact, most vaccines produce antibodies in only 80% of horses. In the horses that it does produce antibodies, they last for a very short time (2 to 3 months); and even though it may produce antibodies this doesn’t mean the horse is protected from acquiring the disease. Currently the studies show that the vaccines are able to effectively reduce the symptoms of the respiratory form of the disease in about 50% of the horses. One last bit of bad news is that none of the vaccines out there are able to protect against the neurologic form of the virus.

So now you are asking, “Why am I vaccinating for this disease it appears that the vaccine doesn’t work?” Short of saying, “I don’t know.” it does appear that multiple vaccination (every 3 months) in high-risk horses, such as show horses, reduces the severity of the disease. In pregnant mares it appears to prevent abortion storms meaning multiple abortions on the same breeding farm; however the disease can and will still occur in individuals, because some horses do not respond at all to the vaccine. So if you are willing to give the vaccine every three months…oh wait there is a problem with doing this as well…. the immune system has a limited capacity for responding to vaccine. If you give it too many vaccines at the same time or space them too closely, you dilute the immune response to each vaccine. So giving multiple vaccines every two to three months over a long period of time will reduce the effectiveness of the vaccine which has a poor effectiveness to begin with. Not to mention that in dogs and cats it has been discovered that multiple vaccinations causes (let me repeat) causes immune system failure such as allergies, cancers and autoimmune diseases. Check out – Is Your Vet overvaccinating your dog? for more information. The horse is a different animal but there is anecdotal evidence in horses with allergies that reducing the number of vaccines up to totally eliminating them reduces the severity of their allergies to the point where they are unnoticable.

So lets bring this back to fall vaccinations…the last time your horse may have received a rhino shot was in the spring. The vaccine, if it produces antibodies in your horse, lasts 2 to 3 months, it is what now 6 months or 9 months later? How effective has that vaccine been in protecting your horse? So why are you wasting your money? So No – Equine Rhino Vaccination is not worth it.

Vaccine Challenge – Australia’s Equine Influenza

Keeping up on the story of Equine Influenza in Australia and the new vaccine being used. The first test, unfortunately or maybe not the vaccine has only had one dose given, is occurring at a race track in Australia. Ususally when the first dose of a vaccine is given antibodies are not produced in a high enough quantity and do not have a sustained duration to actually offer protection. In some vaccines they do. So we will see what occurs… Here is the link to the story…
Vaccine faces first test as virus strikes Rosehill stable

Australia to test out ProteqFlu

We are closer here in the United States to obtain ProteqFlu and Australia with its current problem with Influenza is going to be able to use the vaccine. This is good real good.

Now I know what many of my regular readers are thinking…Dr. Dan why are you excited about a vaccine. Well let me tell you the technology used in this vaccine by Merial is the same technology used in the West Nile Virus vaccine. It is a recombinant DNA technology virus using Canary Pox virus as the vector.

So what does this mean for you… it means you have a vaccine that works and one with less reactions. Here is the study done by Merial – http://avmajournals.avma.org/doi/abs/10.2460/ajvr.68.2.213 I know, I know a study done by the company that makes the vaccine can be a little well you know… biased. SO I did a search for a few others…. and they all showed very good efficacy in fighting off influenza in the horse.

One in particular showed a group of ponies vaccinated with one strain of virus challenged with another genetic shift strain and the ponies at the most had a slight nasal discharge that lasted for one day while the control group became quite ill. One of the first times that there actually was an instance in cross reactivity with a different strain.

You see influenza in people mutates every year in the horse it mutates every 10 years or so, this is called genetic shift of the influenza strains. The last mutation was the 2003 Wisconsin strain, which is the strain suspected (99% gentically similar) to be causing all the havoc in Australia. The last one before that I beleive was the 1997 Kentucky Strain and before that was the 1993 Kentucky Strain, so it is possible that the horse flu has now shifted to an every 5 year genetic shift – if that is the case we should be expecting a genetic shift in the next year or two. SO this vaccine with the prospect of it actually protecting horses with less reactions is very exciting and promising. Lets see what it can do for the Australians and there current problem.

For more information on this check out The Horse they have been doing a great job covering the story in Australia.

Here are a few stories from them…

http://www.thehorse.com/ViewArticle.aspx?ID=10459&nID=6

http://www.thehorse.com/ViewArticle.aspx?ID=10462&nID=6

http://www.thehorse.com/ViewArticle.aspx?ID=10441&nID=6

With all the use over there I will certainly be paying close attention to how effective it is. I have high hopes for Proteqflu as a new generation of vaccine. One that actually works has a long lasting duration of immunity and has less reactions.